Industry-Relevant Models: Robust in vivo models for obesity, diabetes, MASH, and cardiovascular-metabolic diseases that replicate human disease pathways.
Accelerating Breakthroughs in Metabolic Disease Research
Your Trusted CRO Partner in Drug Discovery
At GD3, we specialize in helping biotech and pharmaceutical innovators bring impactful therapies for metabolic diseases to life. Leveraging cutting-edge in vivo and ex vivo models, our contract research services are designed to provide fast, reliable, and translatable insights—so you can move forward with confidence.
Why Partner with GD3?
Custom Study Design: Tailored studies to fit your therapeutic target, pathway, and mechanism of action.
Comprehensive Endpoints: From imaging and biomarkers to histology and metabolic profiling—we provide the data that drives decisions.
Scientific Expertise: Our team brings decades of experience in metabolic research to help guide your project from concept to IND-enabling studies.
Our Preclinical Expertise and Specialized Models in Metabolic Diseases
Obesity & Diabetes Models
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Diet-induced obese mice (DIO)
- Genetic models
- db/db mice (leptin receptor mutation)
- ob/ob mice (leptin mutation)
- Chemical treatment
- Streptozotocin-induced type I diabetic model
- Bred models
- Goto-Kakizaki (GK) rat-type II
- Body composition (lean mass, fat mass, bone) by DEXA
- Oral glucose tolerance test (OGTT)
- HbA1c levels
- Insulin tolerance test (ITT)
- Tissue glycogen levels
- Pancreatic insulin content
- Hormones (Glucagon, GLP-1, adiponectin, leptin, insulin, etc.)
- Hind-limb ischemia (Doppler imaging)
- Cutaneous wound healing
- Diabetic retinopathy
MASH (Metabolic Dysfunction-Associated Steatohepatitis)
- Choline deficient amino acid-defined high-fat diet (CDAA-HFD)
- Streptozotocin-induced type I diabetes/high-fat diet
- High saturated fat/ high fructose diet
- Western diet
- Hepatic fibrosis models (TAA/CCl4)
- Transgenic models (Pten-/- fibrosis model)
- Liver enzymes and lipid panels
- Histopathology with MASH staging by a certified pathologist
- Computer-assisted histology
- Fat composition
- Macrophage infiltration
- Fibrosis
- Liver collagen content
- Galectin-3 levels
MASH Model Induction and Analysis
Cardiovascular & Bone Metabolic Models
- Blood pressure and heart rate model
- N-LMA-induced hypertension model
- Atherogenic diet feeding
- High cholesterol
- Transgenic models
- ldlr -/-
- apoe-/-
- Human CETP
- Ovariectomy (OVX) model of postmenopausal bone loss
Powerful Insights. Predictive Models. Better Outcomes.
Our models are designed not just to replicate disease—but to reveal actionable data that advances your therapeutic pipeline. Whether you’re in early discovery or preparing for IND submission, GD3 offers the translational relevance and scientific rigor you need to succeed.
